State of some longevity therapies (as of mid-2024)

Reading: A primer on the current state of longevity research, by Abhishaike Mahajan and Stacy Li, 27 July 2024.

A very nice kind of Q&A on changes in longevity research over the last 3 years.

• Sirtuin: not worked out.
• Cellular reprogramming: interesting, no trials yet, but being pursued by a bunch of organizations.
• Biological clocks: mixed, shows some promise.

This is my quick memory aid, but check out the source article for the history and reasoning. 

Related to this is the Derek Lowe post cautiously positive on metformin for cognitive function (but only tested in male primates):

This is all good to see, and I hope that human trials will lay down a solid rationale for extending healthy lifespan pharmacologically. This field has seen an awful lot of hype and nonsense over the years, but there are areas with unignorably hard data, and more is coming